Greally lab

Welcome to our lab. We study unusual mechanisms of human disease.

We study transcriptional regulation.

We study DNA sequence variation in the non-coding majority of the genome.

We study cells in a tissue, the fates that created them, mosaicism for DNA sequence variants, and reprogramming of their functions.

We study how genetic ancestry influences disease risk, and how this intersects with social determinants of health and structural racism.

We study rare diseases, and how the insights above allow us to understand why the rare disease occurred in an individual or family.

Our goal is to improve human health, with a focus on the socio-economically disadvantaged and diverse communities of The Bronx.