The Greally Lab studies odd mechanisms of human disease.
Our focus is on how environmental and genetic variability change the transcriptional regulation of a canonical cell type (cellular reprogramming) or the composition of cells in a tissue (polycreodism).
Graduate students
Kassidy Lundy (PhD)
Kassidy is studying the transdifferentiation of iPSC-derived hepatic stellate cells to myofibroblasts, to gain insights into therapeutic targets to block hepatic fibrosis.
Vitamin D Deficiency During Development Permanently Alters Liver Cell Composition and Function
Jacob Stauber (MSTP)
Jacob is co-mentored by Uli Steidl and studies the stem cell origins of clonal haematopoiesis
Preleukemic and leukemic evolution at the stem cell level
Eric Sosa (MSTP)
Eric is studying how de novo variants in the genome are associated with human traits and diseases, with a focus on neurodevelopment.
Eric is the recipient of a Human Genetics Scholar Award from the American Society of Human Genetics.
Marliette Rodriguez Matos (PhD)
Marli is leading the lab’s study of age-associated changes in CD4+ T lymphocytes, using single cell RNA-seq, ATAC-seq, and genotyping. This collaborative project with the lab of Tuuli Lappalainen intends to understand why molecular genomic (epigenomic) changes occur in ageing cells.
David Yang (PhD)
David is co-mentored by population genetics colleague Sri Raj, and is studying how DNA sequence variants influence the function of cells undergoing adipogenic differentiation, with a focus on variants associated with type 2 diabetes susceptibility in Asian populations, in collaboration with colleagues from the Singapore Institute for Clinical Sciences.
Principal investigator
John Greally DMed PhD FACMG
John Greally is trained as a pediatrician and as a clinical geneticist, seeing patients at Montefiore Hospital in the Bronx, and directs Einstein’s Center for Epigenomics. He studies the mechanisms of the diseases he sees in his diverse patients, with a focus on the non-coding genome, transcriptional regulation and cell fate decisions.
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